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. Author manuscript; available in PMC: 2022 May 17.
Published in final edited form as: Dev Cell. 2021 May 17;56(10):1408–1416. doi: 10.1016/j.devcel.2021.04.018

Figure 3. Fuel selection during thermogenesis.

Figure 3.

Glucose, fatty acids (FA), and branched-chain amino acids (BCAA) are necessary for optimal thermogenesis in brown and beige fat. A better understanding of metabolite gating into the mitochondrial matrix is needed to develop a comprehensive model of fuel selection. Genetic or pharmacological regulation of inner mitochondrial membrane (IMM) transport proteins allows for the control of the fate of metabolites from cytosolic actions and that of mitochondrial metabolism action.