Table 3.

ACIP Recommendations for Spacing of Vaccinations^47,64,^a,^b

Antigen Combination	Minimum Interval Between Doses
Two or more inactivatedc	May be administered simultaneously or at any interval between doses
Inactivated and live	May be administered simultaneously or at any interval between doses

ACIP, Advisory Committee on Immunization Practices; CDC, Centers for Disease Control and Prevention; PCV13, 13-valent pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal polysaccharide vaccine; RZV, recombinant zoster vaccine.

^aCDC general recommendations advise that recombinant and adjuvanted vaccines, such as RZV, can be administered concomitantly, at different anatomic sites, with other adult vaccines.

^bThe safety and efficacy of administering 2 adjuvanted vaccines, such as RZV and adjuvanted influenza vaccine (Fluad), have not been assessed.

^cFor patients with immunosuppressive high-risk conditions for whom PCV13 and PPSV23 are indicated, PCV13 should be administered first, and PPSV23 should be administered no earlier than 8 weeks later. For persons 65 years or older for whom PCV13 and PPSV23 are indicated, PCV13 should be administered first, and PPSV23 should be administered 6 to 12 months later.