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. 2021 May 5;12:643275. doi: 10.3389/fmicb.2021.643275

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Copyright © 2021 Pietschmann, Voepel, Voß, Rasche, Schubert, Kleines, Krause, Shaw, Spiegel and Schroeper.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sensitivity and specificity of magnetic immunodetection-based SARS-CoV-2-specific antibody testing. A total of 170 patient sera were previously tested with certified DiaSorin Liaison SARS-CoV-2 S1/S2 IgG assay in clinical environment for the occurrence of SARS-CoV-2-specific antibodies. Afterward, sera were retested using magnetic immunodetection with SARS-CoV-2 S1-His protein coated and blocked ready-to-use immunofiltration columns (RTU-IFCs). After application of sera, followed by subsequent addition of biotinylated human IgG-specific secondary antibody and streptavidin-functionalized magnetic particles, IFCs were measured using a handheld frequency mixing magnetic detection (FMMD) readout device. Each data point represents a patient serum (n = 1). Dashed line indicates the threshold defining, whether sera were positive or negative tested using magnetic immunodetection.