Fig 1.

Proinflammatory cytokine levels in neocortex after lipopolysaccharide treatment. (a) Shown are IL-6 protein concentrations measured via enzyme-linked immunosorbent assay in neocortical homogenate samples from mice (including animals with and without EEG implant) euthanised 4 h after LPS injection. Each point represents log IL-6 concentration (pg ml⁻¹) from samples obtained bilaterally from anterior (ant) or posterior cortex (post). Overlaid symbols (black) represent the within-group mean across all samples. Error bars represent ± standard error of the mean. (b) MCP-1 protein concentration values are shown. MCP-1 samples below the threshold of detection were set to the square root of the lowest observed quantity (1.13). ∗Indicates significant difference from VEH. ^†Indicates significant difference from low LPS. IL-6, interleukin 6; LPS, lipopolysaccharide; MCP-1, monocyte chemoattractant protein-1; VEH, vehicle.