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. 2020 Nov 7;12(1):24–42. doi: 10.1039/d0md00244e

IC50 values of chloroquine–cladinosyl (18 and 19), –aminoquinoline–isatin (20), –imipramine (21 and 22) and –purine (23) hybrids.

Hybrid IC50 (nM) ± SD CQR IC50 (nM) ± SD CQS
18(a, b) 48–295 77–636
19 2–9 3–11
20(a–c) 11.7–24.9 —
21 5 3
22 1.6 9
23(a–h) 80–504 61–187