Table 1.
Comorbidities | Other treatments | ETI/NIV | CRP (mg/dl) | LDH (U/L) | CPK (U/L) | Ferritin (μg/L) | D-Dimer (ng/mL) | Outcome (x109/L) | IL-6 (pg/mL) | Limphocytes | |||||||||||||
a | b | c | a | b | c | a | b | c | a | b | c | a | b | c | a | b | c | ||||||
P1: W, 76y | HTN, DMII, AF | lopinavir/ritonavira | ETI | 68 | 153 | 18 | 293 | 309 | 247 | 46 | 44 | 27 | 302 | 442 | 348 | 774 | 124,9 | 0,37 | 0,90 | 1,35 | Discharged home 22 days after sarilumab | ||
hydroxychloroquine plus azithromycinb,∗∗ | |||||||||||||||||||||||
P2: W, 71y | HTN, DMII | hydroxychloroquine plus azithromycinb | NIV | 221 | 330 | 15 | 608 | 528 | 292 | 424 | 159 | 3771 | 2529 | 2272 | 2036 | – | 0,97 | 0,89 | 1,76 | Discharged home 19 days after sarilumab | |||
P3: M, 78y | HTN, COPD, AF, Obesity | hydroxychloroquine plus azithromycinb | NIV | 143 | 152 | 208 | 287 | 398 | 435 | 869 | 179 | 151 | 1198 | 3394 | 302 | 515 | 380 | 0,64 | 0,47 | 0,57 | Death 2 days. after sarilumab | ||
P4: W, 79y | HTN, DLP CKDIIIa, | hydroxychloroquine plus azithromycinb | NIV | 400 | 480 | 766 | 713 | 160 | 319 | 83275 | 31975 | 65,2 | 0,71 | 0,45 | Death 6days after sarilumab | ||||||||
prednisolone 250 mgc | |||||||||||||||||||||||
P5: M, 62y | HTN, DMII, hepatic fibrosis | hydroxychloroquine plus azithromycinb | NIV | 76 | 123 | 25 | 331 | 334 | 221 | 326 | 581 | 461 | 727 | 856 | 1546 | 98,7 | 1,29 | 1,72 | 1,98 | FiO2(21%) 9 days after sarilumab |
AF = atrial fibrillation, CKD = chronic kidney disease, COPD = chronic obstructive pulmonary disease, DLP = dyslipidemia, DM = diabetes mellitus, ETI = endotracheal intubation, HTN = hypertension, NIV = non invasive ventilation.
At admission.
Before sarilumab.
After sarilumab.
Hydrochloroquine 400 mg/12h (1d) followed by 200 mg/12h (4 more days) plus azithromycin 500 mg/d (3 days).