(A) Immunostaining of EC markers (CD31, VECAD, eNOS and vWF) and pluripotency marker OCT4 in XF-hiPSC-ECs, XG-hiPSC-ECs, XF-HUVECs, XG-HUVECs, and undifferentiated hiPSCs under xenogeneic-free conditions. DNA (nuclear) was counterstained by DAPI. Scale bar: 200 μm. (B) Percentage of cells (XF-hiPSC-ECs, XG-hiPSC-ECs, XF-HUVECs, XG-HUVECs, and xenogeneic-free hiPSCs) positive for EC markers (CD31, VECAD, eNOS and vWF) and pluripotency marker OCT4 from immunostaining (One-way ANOVA with Tukey’s multiple comparisons test; Mean values and S.E.M indicated by error bars are shown; n=3; ****: p<0.00 01; N.S: not significant).