This work is licensed under a Table 2.
Associations among blood lead level, vitamin D, bone turnover markers and metabolic factors.
| Men | Postmenopausal women | |||||
|---|---|---|---|---|---|---|
| 25(OH)D | Vitamin D deficiency | Blood lead level | 25(OH)D | Vitamin D deficiency | Blood lead level | |
| P1NP | −0.12 (−0.18, −0.07) | 0.05 (0.01, 0.09) | 0.05 (0.02, 0.08) | −0.15 (−0.21, −0.10) | 0.12 (0.08, 0.17) | 0.06 (0.03, 0.08) |
| N-MID osteocalcin | −0.11 (−0.17, −0.06) | 0.04 (−0.001, 0.07) | 0.06 (0.03, 0.08) | −0.13 (−0.19, −0.08) | 0.08 (0.04, 0.12) | 0.05 (0.02, 0.07) |
| β-CTX | −0.12 (−0.19, −0.05) | 0.06 (0.01, 0.10) | 0.08 (0.05, 0.12) | −0.16 (−0.23, −0.10) | 0.10 (0.05, 0.15) | 0.06 (0.03, 0.09) |
| BMI | −0.20 (−0.68, 0.28) | 0.38 (0.06, 0.71) | 0.01 (−0.22, 0.25) | −0.52 (−1.05, 0.01) | 0.63 (0.21, 1.05) | 0.37 (0.12, 0.62) |
| FPG | −0.65 (−1.01, −0.29) | 0.40 (0.16, 0.65) | −0.05 (−0.23, 0.12) | −0.16 (−0.50, 0.19) | 0.37 (0.10, 0.64) | −0.06 (−0.22, 0.10) |
| HbA1c | −0.50 (−0.70, −0.29) | 0.28 (0.14, 0.43) | −0.09 (−0.19, 0.01) | −0.18 (−037, 0.001) | 0.23 (0.09, 0.38) | −0.05 (−0.13, 0.04) |
| eGFR | −2.12 (−4.36, 0.11) | 1.78 (0.26, 3.30) | −1.48 (−2.57, −0.40) | −0.73 (−2.69, 1.23) | 0.79 (−0.74, 2.33) | −2.14 (−3.05, −1.23) |
| Total cholesterol | −0.69 (−0.86, −0.53) | 0.37 (0.25, 0.48) | 0.09 (0.01, 0.17) | −0.61 (−0.78, −0.45) | 0.41 (0.28, 0.54) | 0.03 (−0.05, 0.11) |
| Triglycerides | −0.26 (−0.33, −0.18) | 0.11 (0.06, 0.16) | 0.04 (0.01, 0.08) | −0.14 (−0.21, −0.08) | 0.09 (−0.04, 0.14) | 0.04 (0.01, 0.07) |
| HDL-C | −0.07 (−0.10, −0.04) | 0.04 (0.02, 0.07) | −0.001 (−0.02, 0.02) | −0.06 (−0.10, −0.02) | 0.02 (−0.01, 0.06) | −0.01 (−0.03, 0.01) |
| LDL-C | −0.37 (−0.49, −0.25) | 0.20 (0.12, 0.28) | 0.06 (0.002, 0.12) | −0.36 (−0.48, −0.24) | 0.27 (0.17, 0.36) | 0.02 (−0.03, 0.08) |
| Systolic blood pressure | −3.75 (−6.27, −1.24) | 1.82 (0.11, 3.54) | 1.98 (0.76, 3.19) | −2.29 (−4.67, 0.10) | 1.27 (−0.60, 3.14) | 0.35 (−0.76, 1.46) |
| Diastolic blood pressure | −2.61 (−4.10, −1.12) | 1.59 (0.57, 2.60) | 0.56 (−0.16, 1.28) | −0.70 (−2.07, 0.68) | 0.84 (−0.24, 1.92) | 0.47 (−1.17, 1.11) |
A linear regression was performed. The model was adjusted for participant age, current smoking habits, BMI, dyslipidemia, hypertension, vitamin D intake, duration of diabetes and use of anti-osteoporosis medication. 25(OH)D, vitamin D deficiency and blood lead level were independent variables, and bone turnover markers and metabolic factors were dependent variables. 25(OH)D, blood lead level, P1NP, N-MID osteocalcin, β-CTX and triglycerides were natural logarithm-transformed. The bold indicates P < 0.05.
25(OH)D, 25-hydroxy vitamin D; CTX, collagen type 1 C-telopeptide; eGFR, estimated glomerular filtration rate; FPG, fasting plasma glucose; HDL-C, high-density lipoprotein; HbA1c, glycated hemoglobin; LDL-C, low-density lipoprotein; and P1NP, procollagen type 1 N-terminal propeptide.