. 2021 Mar 3;10(4):378–386. doi: 10.1530/EC-21-0006
This work is licensed under a Table 3.
Mediation of bone turnover markers on the association between 25(OH)D and blood lead levels.
| Effect | P1NP | β-CTX | N-MID osteocalcin |
|---|---|---|---|
| Men | |||
| a (exposure→mediator) | −0.128 (−0.186, −0.070) | −0.123 (−0.189, −0.057) | −0.114 (−0.167, −0.061) |
| b (mediator→outcome) | 0.111 (0.032, 0.191) | 0.148 (0.078, 0.217) | 0.138 (0.050, 0.225) |
| c (total effect) | −0.022 (−0.119, 0.075) | −0.022 (−0.119, 0.075) | −0.022 (−0.119, 0.075) |
| c’(direct effect) | −0.008 (−0.105, 0.090) | −0.004 (−0.101, 0.094) | −0.006 (−0.104, 0.091) |
| ab (mediated effect) | −0.014 (−0.029, −0.003) | −0.018 (−0.034, −0.006) | −0.016 (−0.032, −0.004) |
| Postmenopausal women | |||
| a (exposure→mediator) | −0.144 (−0.200, −0.088) | −0.149 (−0.210, −0.087) | −0.125 (−0.175, −0.075) |
| b (mediator→outcome) | 0.129 (0.052, 0.206) | −0.104 (0.033, 0.175) | 0.105 (0.019, 0.192) |
| c (total effect) | −0.078 (−0.174, 0.018) | −0.078 (−0.174, 0.018) | −0.078 (−0.174, 0.018) |
| c’(direct effect) | −0.060 (−0.157, 0.036) | −0.063 (0.160, 0.033) | −0.066 (−0.162, 0.031) |
| ab (mediated effect) | −0.019 (−0.036, −0.005) | −0.016 (−0.030, −0.005) | −0.013 (−0.029, −0.001) |
The model was adjusted for current smoking habits, vitamin D intake, BMI, dyslipidemia, hypertension, estimated glomerular filtration rate, duration of diabetes and use of anti-osteoporosis medication. 25(OH)D, blood lead level, P1NP, N-MID osteocalcin and β-CTX were natural logarithm-transformed. The bold indicates P < 0.05.
25(OH)D, 25-hydroxy vitamin D; CTX, collagen type 1 C-telopeptide; and P1NP, procollagen type 1 N-terminal propeptide.