Search methods
Expertise	The searches will be verified by a content expert, conducted by an Information Specialist, and independently peer reviewed.
Electronic databases	Database [minimum checked – please specify one other] ☒ MEDLINE ☒ CENTRAL ☒ Embase ☒ Other ‐ Cochrane COVID‐19 Study Register ☐ Clinical Trial Registry (please specify)	From: Inception		To: 01/05/2020
Other searches	☒ Systematic review references ☒ Reference lists of included studies ☐ Grey literature (please specify) ☐ Citation tracking ☐ Data from the pharmaceutical industry ☐ Contact experts for references ☐ Other (please specify)
Approach to ongoing and unpublished studies	☐ Include ongoing studies ☐ Unpublished studies ☐ Studies in press ☒ Exclude all studies that are ongoing, unpublished, or in press	Through handsearching references and including ongoing trials across major databases
Methods for screening search results
Expertise	Screening will be performed by AO/AC
Screening methods	Dual; second reviewer checks all excluded records Dual; second reviewer checks [X%] of excluded records Dual; independent screen and cross check		Abstract ☐ ☐ ☒		Full text ☐ ☐ ☒
Discrepancy resolution	☒ Consensus and/or third reviewer ☐Other (please specify)
Excluded studies	All decisions taken during full‐text screening will be documented and outlined in the final report with a list of excluded studies.
Inclusion of abstracts and conference proceedings	☐ Exclude all ☒ Include if clearly eligible and have useable data ☐ Include if clearly eligible regardless of useable data ☐ Include if eligibility is unclear and add to section in report
Inclusion of non‐English language studies	☒ Include abstracts and full texts [in Chinese/any language] ☐ Include full texts only [in Chinese only/ language] ☐ Exclude
	☒ All potentially relevant abstracts will progress to full‐text screen ☐ [Single/dual] title/abstract screen by foreign‐language speaker(s) ☒ [Abstract/methods/full text] will be translated for abstract/full text screen ☐ Listed as non‐English language and not assessed further