Table 4. Plasma levels of angiogenic factors between cases and controls by gestational age groups.

Angiogenic factors	GA categories (weeks)	Controls (IQR)	Cases (IQR)	p-value
VEGF (pg/ml)	20–28	1.37 (0.94–2.81)	1.49 (0.39–1.62)	0.6496
	29–33	1.12 (0.78–2.17)	0.61 (0.29–1.12)	0.0033
	34–37	1.41 (0.81–2.62)	0.76 (0.45–1.06)	0.0017
	38–42	1.05 (0.41–1.54)	0.71 (0.36–1.09)	0.2784
PlGF (pg/ml)	20–28	92.89 (65.42–104.95)	0.84 (0.60–0.99)	< 0.001
	29–33	89.87 (36.43–169.16)	2.17 (1.31–17.52)	< 0.001
	34–37	104.95 (42.68–158.10)	2.07 (1.03–4.16)	< 0.001
	38–42	57.36 (22.37–131.28)	3.06 (1.51–6.52)	< 0.001
sFlt1 x103 (pg/ml)	20–28	14.39 (6.45–25.88)	220.54 (171.75–259.30)	< 0.001
	29–33	17.21 (12.90–20.42)	146.90 (69.02–198.25)	< 0.001
	34–37	23.34 (14.58–29.01)	167.95 (92.58–216.02)	< 0.001
	38–42	22.77 (17.74–37.83)	112.39 (66.35–191.51)	< 0.001
sFlt1/ PlGF ratio (x103)	20–28	0.15 (0.10–0.36)	233.81 (155.64–314.20)	< 0.001
	29–33	0.14 (0.09–0.37)	73.23 (7.02–173.36)	< 0.001
	34–37	0.19 (0.10–0.44)	86.85 (30.27–151.18)	< 0.001
	38–42	0.48 (0.16–1.27)	25.41(10.09–158.62)	< 0.001

All results are presented as median (IQR (Interquartile range))

GA, gestational age; PlGF, placental growth factor; VEGF, vascular endothelial growth factor; sFlt1, soluble fms like tyrosine kinase; sFlt1/PlGF, soluble fms like tyrosine kinase/placental growth factor ratio.