Table 6. Predictive characteristics of angiogenic factors.
| Angiogenic factors | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) |
NPV (95% CI) |
AUC (95% CI) |
Probability cut-off values |
|---|---|---|---|---|---|---|
| VEGF | 0.56 (0.46–0.65) | 0.69 (0.60–0.77) | 0.64 (0.54–0.74) | 0.61 (0.52–0.70) | 0.66 (0.59–0.73) | 0.4592 |
| PlGF | 0.86 (0.79–0.92) | 0.90 (0.84–0.95) | 0.89 (0.83–0.95) | 0.86 (0.80–0.93) | 0.94 (0.91–0.97) | 0.4534 |
| sFlt1 | 0.89 (0.83–0.95) | 0.89 (0.83–0.95) | 0.89 (0.83–0.95) | 0.89 (0.83–0.95) | 0.95 (0.93–0.98) | 0.4359 |
| sFlt1/ PlGF ratio | 0.92 (0.87–0.97) | 0.91 (0.85–0.96) | 0.91 (0.85–0.96) | 0.92 (0.87–0.97) | 0.95 (0.93–0.98) | 0.4359 |
PlGF, placental growth factor; VEGF, vascular endothelial growth factor; sFlt1, soluble fms like tyrosine kinase; sFlt1/PlGF, soluble fms like tyrosine kinase/placental growth factor ratio; PPV, positive predictive value; NPV, negative predictive value; AUC, Area under curve; CI, confidence interval.