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. 2020 Dec 14;185(3):577–592. doi: 10.1093/plphys/kiaa056

Figure 1.

Figure 1

Schematic representation of the two membrane territories and gradient-powered lipid exchanges at ER–plasma membrane and ER–TGN contact sites in yeast and animal cells. On the left, the electrostatic and the lipid packing defects territories are represented in blue and gray, respectively. On the right, ER–plasma membrane and ER–Golgi lipid gradients and lipid exchanges at contact sites in yeast and animal cells. Lipid transfer proteins that counter transport PA/PI are in green, PI4P/sterol are in lavender, PI4P/PS are in coral, and PC/PI are in mauve. Cellular compartment abbreviations: PM, plasma membrane. Protein abbreviations: Nir2, N-terminal domain-interacting receptor 2; PI4KIIIα/β, class III phosphatidylinositol 4-kinase alpha and beta; VAMP, vesicle-associated membrane protein; VAP, VAMP-associated protein; Ist2, increased sodium tolerance protein 2; Scs2, choline sensitivity suppressor 2; Sac1, suppressor of actin 1; sec14, secretion 14 protein; ORP, oxysterol-related protein; Osh, OSBP homology; PSS1, PS synthase 1; Stt4, staurosporine and temperature-sensitive 4; Pik1, phosphatidylinositol 4-kinase 1. Protein domain abbreviations: PH, pleckstrin homology; TM, transmembrane region.