Table 1.

Studies reporting varying effects of autophagy on primordial follicle formation.

Author	Mouse Strain	Autophagy	System	Treatment	Time	Primordial Follicle Formation	Oocyte Number
Sun et al., 2020	CD1	activate	Organ culture	100 uM Rapamycin	PND 0–3	increased	no change
Sun et al., 2018	CD1	activate	Organ culture	300 nM Rapamycin	PND* 0–3	reduced	increased
Zhang et al., 2017	CD1	activate	Organ culture	250 nM Rapamycin	18.5 – 19.5 dpc	reduced	no change
Zhihan et al., 2019	K	activate	Organ culture	100 nM Rapamycin	17.5 dpc-PND 3	no change	no change
Sun et al., 2018	CD1	inhibit	Organ culture	10 mM 3-MA	PND* 0–3	increased	reduced
Sun et al., 2020	CD1	inhibit	Organ culture	1 mM 3-MA	PND 0–3	reduced	no change
Zhihan et al., 2019	K	inhibit	Organ culture	1 mM 3-MA	17.5 dpc-PND 3	reduced	no change
Zhihan et al., 2019	K	inhibit	In vivo injection	15ug/gram body weight/ day 3-MA	PND 0–3	reduced	no change
Sun et al., 2020	CD1	activate	In vivo	starvation	PND 0–1.5	increased	increased (but n=1)
Watanabe & Kimura, 2018	B6	activate	In vivo	starvation	PND 0.5–1.5	increased	not reported
Wang et al 2017	CD1	activate	In vivo	starvation	PND 1.5–3	reduced	no change
Sun et al., 2020	CD1	activate	In vivo	starvation	PND 0–2	no change	no change
Sun et al., 2020	CD1	activate	Organ culture	miR378–3 overexpression	PND 0–3	increased	no change
Watanabe et al., 2020	B6	activate	In vivo injection	TAT-Beclin 1 D11 peptide	PND 0–2.5	increased	no change
Sun et al., 2020	CD1	inhibit	Organ culture	miR378–3 inhibition	PND 0–3	reduced	no change

^*started culture at 17.5 dpc for 2 days then treated for the following 3 days to the equivalent of PND 3.