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. 2021 May 19;7(21):eabg6165. doi: 10.1126/sciadv.abg6165

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 1 — Virus-infected cells, cancers, and lymphocytes rewire cell metabolism to promote anabolism in general and that of nucleic acids specifically as building blocks for their enhanced proliferation. In addition to the “Warburg effect” that enhances glycolysis, the scheme depicts the metabolic reprogramming that is promoted by major signaling pathways such as p53, MYC, mitogen-activated protein kinase (MAPK), and mTOR to increase nucleotide synthesis (red arrows) for carbon (C) and nitrogen (N) utilization. UCD, urea cycle dysregulation; SLC, solute carrier; THF, tetrahydrofolate; TCA, tricarboxylic acid, MTp53, mutated p53; and OXA, oxaloacetate.