Table 3. Antidepressant use and psychosocial intervention during the trial multi-subject trials.

SSRI: selective serotonin reuptake inhibitor; SNRI: serotonin and norepinephrine reuptake inhibitor, ATHF: Antidepressant Treatment History Form, TCA: tricyclic antidepressants.

Author	Antidepressant use	Previous treatment failure	Psychosocial intervention used	Change of dosages allowed
Croarkin et al. [43]	None	Yes	No change in psychosocial interventions	N/A
Zhang et al. [42]	All used one type of antidepressant treatment during rTMS along with other medications	Unspecified but excluded patients who were taking more than one antidepressant	Unspecified	No
MacMaster et al. [27]	Psychotropic medications use were allowed if stable for 6 weeks 31.25% were not on psychotropics	At least two previous failed medication trials	Unspecified	No unless medically necessary
Pan et al. [38]	Either drug naïve or was not taking antidepressants for 2 weeks prior to the study	All three patients took an antidepressant in the past for an unspecified dose and duration	Unspecified	N/A
Wall et al. [28]	All used either SSRI or SNRI	At least one prior medication trial failure as defined by ATHF. Study participants had a mean of 4.0 prior failed medication trial (SD 2.1).	No change in psychotherapy treatment was allowed within the last 4 weeks of treatment	No
Croarkin et al. [29]	All were on antidepressants	At least one prior failed medication trials	Unspecified	No
Yang et al. [39]	Unspecified	At least one failed trial	Unspecified	Unspecified
Wall et al. [30]	All were on antidepressants	At least one prior failed trial	No change in psychotherapy or therapist	No
Wall et al. [31]	Yes	Yes - at least two failed trials	No change in psychotherapy or therapist in 4 weeks prior to rTMS	No
Croarkin et al. [40]	Case 1 - none; Case 2 - yes	Case 1 - none; case 2 - multiple	Unspecified	No
Bloch et al. [32]	Yes	Failure of one course of psychotherapy and two courses of medication trials 8 weeks each, with at least one of the antidepressants being Fluoxetine	No change in therapy within 5 weeks before starting of rTMS	No
Loo et al. [41]	Case 1 - unspecified; case 2 - yes	Case 1 - failure of one course of psychotherapy; case 2 - one course of psychotherapy, two medication trials	Unspecified	Case 1 - unspecified; Case 2 - no
Walter et al. [44]	No	Unspecified	Unspecified	Unspecified