Figure 6. Mechanosensitive feedback generates self-organized patterns of cell morphology.

(A) We introduce mechanosensitive feedback into our model with a dynamic equation relating the orientational cue $\mathit{q}$ to tissue stress. With a change in $\mathit{q}$, there can be a change in polarity-driven cell rearrangements and stress. (B) Above a critical value of ${\displaystyle \mu }$, the isotropic state is unstable and the system spontaneously polarizes. (C) Application of the model to the radially symmetric wing disc. Generation of large-scale tissue polarity requires the orientation coupling term $D$. We find a set of parameters that can account for the experimental data on cell elongation in the wing disc (see Appendix 1 part 4 and Table 1).