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. 2021 May 4;10:e58741. doi: 10.7554/eLife.58741

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© 2021, Stepanova et al

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Figure 2. — (a) Pathway sketch illustrating the role of ADSL in purine biosynthesis. (b) Differences in metabolite levels between humans (n = 4) and chimpanzees (C) (n = 4), macaques (M) (n = 4) and the two non-human primates combined (P) in prefrontal cortex (PFC), cerebellum (CB), primary visual cortex (VC) analyzed by CE-MS. LC-MS measurements in PFC are from Kurochkin et al., 2019 and involved 40 humans, chimpanzees and macaques, respectively. Red and blue colors indicate higher and lower levels in humans, respectively. c and d. The distributions of metabolite differences between humans and non-human primates for purines biosynthesis (PB) (listed in panel b) and other metabolites (non-PB) detected by CE-MS (c) and LC-MS (d). The Y axis shows fold-change difference between humans and non-human primates. The metabolite concentration values are normalized and log-transformed. Wilcoxon tests for the differences between PB and non-PB distributions: p=0.049 (PFC), p=0.002 (CB), p=0.001 (VC), and p=0.019 (PFC LC-MC).