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. 2021 Apr 8;6(7):e145704. doi: 10.1172/jci.insight.145704

Figure 7. Antimicrobial activity of gentamicin is unaffected by the presence of UoS-7692.

Figure 7

Box-and-whisker plots of ATP luminescence as a measure of bacterial viability in Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa grown in 2.2 μM gentamicin in the presence or absence of 11 μM UoS-7692. There was no change in the bactericidal activity of gentamicin in the presence of UoS-7692. UoS-7692 was tested with 3 technical replicates and 3 independent biological replicates. Midline = median, boxes = IQR, whiskers = an additional 1.5 × IQR; replicates are shown as open circles with biological replicates grouped by color. Staphylococcus aureus (t = 1.55, df = 14, P = 0.143), Klebsiella pneumoniae (t = 1.44, df = 13, P = 0.175), and Pseudomonas aeruginosa (t = 1.71, df = 14, P = 0.11) using a linear mixed-effects model.