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A) SPR transmission spectra, normalized to the spectrum in air, incubating different concentration of SARS-CoV-2 spike protein (25 ÷ 1000 nM) in human serum diluted 1:50 in phosphate buffer on the apt1C- aptamer functionalized POF. Inset: zoom of the resonance wavelengths region. B) Plot of the resonance shift (Δλ), with respect to the blank, versus the spike protein concentration (nM) diluted in human serum (1:50 v/v), reporting also the Langmuir fit.
