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Region of interest (ROI) placement on the reconstruction of corticospinal tract (CST) at the level of precentral gyrus (A, white) and lower pons (B, orange). Fiber tracking images of a healthy subject (C) and a patient with amyotrophic lateral sclerosis (ALS) (D). The rectangle in C indicates section location of ROIs. Descending fibers connecting the cortex and brain stem are shown in purple. CSTs are green. The CST fibers are diminished in the patient with ALS (D).
