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. 2021 Apr 21;19:2775–2789. doi: 10.1016/j.csbj.2021.03.033

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Characterization of hypoxia to predict prognosis of HCC. (A) Deviation plot of 44 differentially expressed hypoxia-related genes (p < 0.05, |logFc|>1); (B) Protein-Protein Interaction interactions among 15 hypoxia-related genes filtered by univariate Cox regression; (C) Construction of a hypoxia-risk model to predict HCC prognosis by multivariate Cox regression; (D) Correlation analysis of four hypoxia genes from GeneMANIA; (E) Immunohistochemistry of DCN/DDIT4/NDRG1/PRKCA in tissue microarray (1× and 40×); (F–G) Relationship between DCN/DDIT4/NDRG1/PRKCA and clinical characteristics in tissue microarray; (H) Kaplan-Meier analysis of DCN/DDIT4/NDRG1/PRKCA in tissue microarray.