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. 2021 Apr 29;40(20):3510–3532. doi: 10.1038/s41388-021-01698-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Increased MRE11 mRNA expression in oral cancer tissues, in comparison to normal tissues, from our database. B Increased MRE11 mRNA expression in oral cancer tissues, in comparison to normal tissues, reported in online databases. C A negative correlation between MRE11A mRNA level and DNA methylation level in the putative promoter region of MRE11, reported in an online database. D Immunohistochemical staining for MRE11 protein expression in oral noncancerous and cancer tissues. E Quantitative result for MRE11 expression in oral noncancerous and cancer tissues. F Overall survival and progression-free survival for high and low MRE11 protein expression groups from our dataset. G Overall survival and progression-free survival for high and low MRE11 mRNA expression groups reported in an online database.

Fig. 1 — A Increased MRE11 mRNA expression in oral cancer tissues, in comparison to normal tissues, from our database. B Increased MRE11 mRNA expression in oral cancer tissues, in comparison to normal tissues, reported in online databases. C A negative correlation between MRE11A mRNA level and DNA methylation level in the putative promoter region of MRE11, reported in an online database. D Immunohistochemical staining for MRE11 protein expression in oral noncancerous and cancer tissues. E Quantitative result for MRE11 expression in oral noncancerous and cancer tissues. F Overall survival and progression-free survival for high and low MRE11 protein expression groups from our dataset. G Overall survival and progression-free survival for high and low MRE11 mRNA expression groups reported in an online database.