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. 2021 Apr 29;40(20):3510–3532. doi: 10.1038/s41388-021-01698-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A An example of oral cancer cell migration in zebrafish. B Quantitation of the effects of MRE11 knockdown and overexpression in oral cancer cells on migration in zebrafish model. C The effect of MRE11 overexpression in oral cancer cells on total flux of lung metastasis. D The effect of MRE11 overexpression in oral cancer cells on metastatic lung tumor area. E–H The effect of MRE11 overexpression in oral cancer cells on the expression of MRE11, RUNX2, CXCR4, and pAKT in metastatic lung tumor tissues. I CXCR4 neutralizing antibody reverse the cancer metastasis promoted by MRE11 overexpression in mouse model. Representative microscopic views of the lung sections. Hematoxylin-positive blue-colored nodules indicate metastatic colony number (Student’s t test) and tumor area (%) (Mann–Whitney U test). J Schematic diagram for MRE11 signaling pathway and activity.

Fig. 6 — A An example of oral cancer cell migration in zebrafish. B Quantitation of the effects of MRE11 knockdown and overexpression in oral cancer cells on migration in zebrafish model. C The effect of MRE11 overexpression in oral cancer cells on total flux of lung metastasis. D The effect of MRE11 overexpression in oral cancer cells on metastatic lung tumor area. E–H The effect of MRE11 overexpression in oral cancer cells on the expression of MRE11, RUNX2, CXCR4, and pAKT in metastatic lung tumor tissues. I CXCR4 neutralizing antibody reverse the cancer metastasis promoted by MRE11 overexpression in mouse model. Representative microscopic views of the lung sections. Hematoxylin-positive blue-colored nodules indicate metastatic colony number (Student’s t test) and tumor area (%) (Mann–Whitney U test). J Schematic diagram for MRE11 signaling pathway and activity.