Table 5.
Interaction between treatment arm and both oestrogen receptor (ER) and menopausal status on patterns of recurrence.
| First site[s] of recurrence | ER −ve patients | ER +ve/unknown patients | ||||
|---|---|---|---|---|---|---|
| All | Control | Zol | All | Control | Zol | |
| n = 706 | n = 356 | n = 350 | n = 2653 | n = 1322 | n = 1331 | |
| Number of recurrences [%] | Number of recurrences [%] | Number of recurrences [%] | Number of recurrences [%] | Number of recurrences [%] | Number of recurrences [%] | |
| All first recurrences | 287 [41%] | 143 [40%] | 144 [41%] | 715 [27%] | 363 [28%] | 352 [26%] |
| Distant +/− local | 212 [30%] | 102 [29%] | 110 [31%] | 612 (23%) | 321 [24%] | 291 [22%] |
| Distant recurrence only | 175 [25%] | 83 [23%] | 92 [26%] | 546 [21%] | 285 [22%] | 261 [20%] |
| Distant + local Recurrence | 37 [5.2%] | 19 [5.3%] | 18 [5.1%] | 66 [2.5%] | 36 [2.7%] | 30 [2.3%] |
| Bone only distant recurrence | 31 [4.4%] | 19 [5.3%] | 12 [3.4%] | 217 [8.2%] | 125 [9.5%] | 92 [7.0%] |
| Extraskeletal distant recurrence +/− bone | 181 [26%] | 83 [23%] | 98 [28%] | 395 [15%] | 196 [15%] | 199 [15%] |
| Extraskeletal recurrence only | 145 [21%] | 59 [17%] | 86 [25%] | 222 [8.4%] | 107 [8.1%] | 115 [8.7%] |
| Local +/− distant | 114 [16%] | 60 [17%] | 52 [15%] | 169 [6.4%] | 78 [5.9%] | 91 [6.9%] |
| Local Recurrence | 77 [11%] | 41 [12%] | 34 [9.7%] | 103 [3.9%] | 42 [3.2%] | 61 [4.6%] |
| Postmenopausal status | Pre/peri and uncertain menopausal status | |||||
| All | Control | Zol | All | Control | Zol | |
| n = 1041 | n = 522 | n = 519 | n = 2318 | n = 1156 | n = 1162 | |
| Number of recurrences [%] | Number of recurrences [%] | Number of recurrences [%] | Number of recurrences [%] | Number of recurrences [%] | Number of recurrences [%] | |
| All first recurrences | 313 [30%] | 167 [32%] | 136 [26%] | 699 [30%] | 339 [29%] | 360 [31%] |
| Distant +/− local | 252 [24%] | 136 [26%] | 116 [22%] | 572 [25%] | 287 [25%] | 285 [25%] |
| Distant recurrence only | 221 [21%] | 116 [22%] | 105 [20%] | 500 [22%] | 252 [22%] | 248 [21%] |
| Distant + local Recurrence | 31 [3.0%] | 20 [3.8%] | 11 [2.1%] | 72 [3.1%] | 35 [3.0%] | 37 [3.2%] |
| Bone only distant recurrence | 66 [6.3%] | 36 [6.9%] | 30 [5.8%] | 182 [7.9%] | 108 [9.3%] | 74 [6.4%] |
| Extraskeletal distant recurrence +/− bone | 186 [18%] | 100 19%] | 86 [17%] | 394 [17%] | 179 [15%] | 215 [19%] |
| Extraskeletal recurrence only | 117 [11%] | 61 [12%] | 56 [11%] | 260 [11%] | 105 [9.1%] | 155 [13%] |
| Local +/− distant | 82 [7.9%] | 51 [9.8%] | 31 [6.0%] | 199 [8.9%] | 87 [7.5%] | 112 [9.6%] |
| Local Recurrence | 51 [4.9%] | 31 [5.9%] | 20 [3.9%] | 127 [5.5%] | 52 [4.5%] | 75 [6.5%] |