Table 3.
Tmax and Cmax values of 25(OH)D3 and its each metabolite with single dose administration of 25(OH)D3 to WT or Cyp24a1 KO rats at 15 weeks of age
| Strain | Vitamin D3 metabolites | Tmax (h) | Cmax (nM) |
|---|---|---|---|
| WT | 25(OH)D3 | 3.0 ± 1.1 | 370 ± 150 |
| 24,25(OH)2D3 | 4.3 ± 0.8 | 436 ± 164 | |
| 24-oxo-25(OH)D3 | 4.7 ± 1.0 | 101 ± 29 | |
| 24-oxo-23,25(OH)2D3 | 4.8 ± 1.8 | 84 ± 31 | |
| tetranor-23(OH)D3 | 5.0 ± 2.0 | 6.8 ± 1.3 | |
| 26,23-lactone-25(OH)D3 | 10.7 ± 2.1 | 195 ± 48 | |
| Cyp24a1 KO | 25(OH)D3 | 5.3 ± 1.0 | 1460 ± 630 |
The values are shown as the mean ± SD. (n = 5–7; biological replicates).