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. 2021 Jan 23;155(5):605–615. doi: 10.1007/s00418-021-01962-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Clca2 is downmodulated by UVR. a REK organotypic cultures (9 days) were either sham-treated or UVB-exposed, and samples were collected at the indicated time points and analyzed for rClca2 mRNA. The Ct-value of the sham-treated culture was set as 1 at each time point and the mRNA level of the UV-exposed culture was compared to it. The data represent means and SE from 3 individual experiments, each performed with duplicate cultures. The statistical differences were tested using 2-way ANOVA with Bonferroni’s Post Hoc test. **p < 0.01. b–f Histological sections from 14 sham (b) or 14 UVR (c–f)-exposed mouse back skins were stained with anti-CLCA2 antibody. b The sham-exposed skin with normal epidermal morphology shows intense, regular immunostaining in the epidermis. Both basal and the suprabasal cells are CLCA2 positive (b, inset) as well as the hair follicles and sebaceous glands. c A UVR-exposed specimen with strong epidermal hyperplasia showing irregular, focally reduced CLCA2 staining (arrowhead). d–f A UVR-exposed specimen with SCC. d Overview, e an area with focally reduced CLCA2 immunostaining, f an area with intense regular staining. Similar irregular pattern was observed in all 5 SCCs and 8 hyperplastic areas found in the specimens. Magnification bars 50 µm