Table 1.
Hematology—expanded single dose intravenous toxicity study of 211At-NaAt in mice –
| Inspection time | Sex | Group | RBC | Hb | Ht | MCV | MCH | MCHC | WBC | Platelet | %Lymph | %Mon | %Gra | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (× 106cell/μL) | (g/dL) | (%) | (fL) | (pg) | (g/dL) | (× 103cell/μL) | (× 103cell/μL) | (%) | (%) | (%) | ||||
| 5 days after administration | Male | Control | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
| Mean | 8.48 | 14.5 | 44.1 | 52.1 | 17.1 | 32.9 | 6.9 | 1300.2 | 64.8 | 4.3 | 31.0 | |||
| ± S.D | ± 0.54 | ± 1.0 | ± 3.1 | ± 1.4 | ± 0.5 | ± 0.6 | ± 5.4 | ± 480.7 | ± 17.9 | ± 4.2 | ± 14.9 | |||
| 5 MBq/kg | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
| Mean | 8.13 | 14.1 | 42.4 | 52.3 | 17.4 | 33.3 | 4.6 | 1091.5 | 66.3 | 4.2 | 29.6 | |||
| ± S.D | ± 1.20 | ± 1.8 | ± 6.1 | ± 0.8 | ± 0.6 | ± 1.0 | ± 3.6 | ± 315.5 | ± 15.2 | ± 3.6 | ± 13.0 | |||
| 20 MBq/kg | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 9 | 9 | 9 | ||
| Mean | 8.30 | 14.4 | 43.3 | 52.2 | 17.3 | 33.3 | 2.4* | 1036.8 | 73.3 | 2.5 | 24.2 | |||
| ± S.D | ± 0.35 | ± 0.7 | ± 2.4 | ± 1.1 | ± 0.5 | ± 0.6 | ± 3.4 | ± 301.8 | ± 9.1 | ± 1.1 | ± 8.8 | |||
| 50 MBq/kg | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 7 | 7 | 7 | ||
| Mean | 8.11 | 13.8 | 42.1 | 51.9 | 17.0 | 32.8 | 1.6* | 623.7* | 70.1 | 3.6 | 26.3 | |||
| ± S.D | ± 1.00 | ± 1.8 | ± 5.3 | ± 1.0 | ± 0.4 | ± 0.3 | ± 2.3 | ± 314.0 | ± 12.8 | ± 1.6 | ± 12.0 | |||
| 5 days after administration | Female | Control | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
| Mean | 8.60 | 15.1 | 45.1 | 52.5 | 17.5 | 33.3 | 5.3 | 1003.5 | 62.8 | 3.8 | 33.4 | |||
| ± S.D | ± 0.42 | ± 0.8 | ± 2.3 | ± 1.2 | ± 0.3 | ± 0.4 | ± 3.1 | ± 198.4 | ± 13.6 | ± 3.5 | ± 10.8 | |||
| 5 MBq/kg | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
| Mean | 8.78 | 15.2 | 45.9 | 52.4 | 17.3 | 33.1 | 4.7 | 1105.3 | 69.1 | 2.5 | 28.4 | |||
| ± S.D | ± 0.58 | ± 1.0 | ± 2.8 | ± 1.8 | ± 0.8 | ± 0.5 | ± 2.5 | ± 143.0 | ± 4.7 | ± 0.7 | ± 4.4 | |||
| 20 MBq/kg | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
| Mean | 8.90 | 15.4 | 46.4 | 52.2 | 17.3 | 33.2 | 3.2 | 913.3 | 68.4 | 2.9 | 28.7 | |||
| ± S.D | ± 0.31 | ± 0.4 | ± 1.7 | ± 2.0 | ± 0.6 | ± 0.4 | ± 3.4 | ± 236.8 | ± 9.5 | ± 1.9 | ± 9.0 | |||
| 50 MBq/kg | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 7 | 7 | 7 | ||
| Mean | 8.53 | 15.1 | 44.8 | 52.5 | 17.6 | 33.6 | 1.3* | 613.5* | 64.6 | 3.7 | 31.6 | |||
| ± S.D | ± 0.31 | ± 0.8 | ± 2.3 | ± 1.5 | ± 0.5 | ± 0.4 | ± 1.5 | ± 176.1 | ± 19.8 | ± 2.1 | ± 18.2 | |||
| 14 days after administration | Male | Control | N | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Mean | 8.41 | 14.5 | 42.9 | 51.0 | 17.2 | 33.8 | 4.8 | 1139.2 | 69.5 | 2.4 | 28.1 | |||
| ± S.D | ± 0.73 | ± 1.7 | ± 4.0 | ± 0.6 | ± 0.5 | ± 0.8 | ± 3.7 | ± 187.4 | ± 11.4 | ± 2.0 | ± 9.4 | |||
| 50 MBq/kg | N | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | ||
| Mean | 7.76 | 13.7 | 40.7 | 52.5 | 17.7 | 33.7 | 4.3 | 1028.6 | 44.6* | 4.7 | 50.8* | |||
| ± S.D | ± 0.32 | ± 0.7 | ± 2.4 | ± 1.4 | ± 0.4 | ± 0.6 | ± 3.1 | ± 75.7 | ± 11.1 | ± 2.6 | ± 9.6 | |||
| Female | Control | N | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |
| Mean | 8.90 | 15.1 | 45.5 | 51.3 | 17.0 | 33.2 | 6.3 | 1396.3 | 72.3 | 3.2 | 24.6 | |||
| ± S.D | ± 0.50 | ± 0.5 | ± 1.0 | ± 2.6 | ± 0.5 | ± 0.8 | ± 3.9 | ± 346.0 | ± 14.6 | ± 3.2 | ± 11.4 | |||
| 50 MBq/kg | N | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | ||
| Mean | 8.73 | 15.1 | 44.8 | 51.4 | 17.2 | 33.6 | 5.0 | 1085.0 | 61.0 | 3.4 | 35.6 | |||
| ± S.D | ± 0.23 | ± 0.4 | ± 1.7 | ± 1.2 | ± 0.4 | ± 0.5 | ± 2.8 | ± 73.2 | ± 9.7 | ± 1.3 | ± 9.0 |
RBC Red blood cell, Hb Hemoglobin, Ht Hematocrit, MCV Mean corpuscular volume, Gra Granulocyte, WBC White blood cell, MCH Mean corpuscular hemoglobin level, Lym Lymphocyte, MCHC Mean corpuscular hemoglobin concentration, Mon Monocyte
Significantly different from the control, *p<0.05. (Dunnett-test)