Table 2.
Blood chemistry—expanded single dose intravenous toxicity study of 211At-NaAt in mice -
| Inspection time | Sex | Group | AST | ALT | γ-GTP | LDH | ALP | CK | AMY | TBIL | CRE | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (IU/L) | (IU/L) | (IU/L) | (IU/L) | (IU/L) | (IU/L) | (IU/L) | (mg/dL) | (mg/dL) | ||||
| 5 days after administration | Male | Control | N | 10 | 8 | 0 | 8 | 10 | 8 | 10 | 10 | 3 |
| Mean | 55 | 18 | – | 1047 | 368 | 353 | 2908 | 0.59 | 0.27 | |||
| ± S.D | ± 22 | ± 7 | – | ± 459 | ± 79 | ± 266 | ± 435 | ± 0.25 | ± 0.06 | |||
| 5 MBq/kg | N | 8 | 7 | 0 | 8 | 9 | 9 | 9 | 8 | 0 | ||
| Mean | 47 | 24 | – | 1170 | 356 | 394 | 2578 | 0.58 | – | |||
| ± S.D | ± 20 | ± 15 | – | ± 271 | ± 129 | ± 327 | ± 547 | ± 0.25 | – | |||
| 20 MBq/kg | N | 9 | 8 | 0 | 6 | 10 | 9 | 10 | 9 | 1 | ||
| Mean | 56 | 32 | – | 880 | 335 | 407 | 2853 | 0.59 | 0.20 | |||
| ± S.D | ± 31 | ± 41 | – | ± 329 | ± 85 | ± 176 | ± 417 | ± 0.24 | – | |||
| 50 MBq/kg | N | 10 | 9 | 0 | 9 | 10 | 10 | 8 | 10 | 0 | ||
| Mean | 43 | 20 | – | 546** | 309 | 344 | 3019 | 0.60 | – | |||
| ± S.D | ± 23 | ± 10 | – | ± 123 | ± 59 | ± 194 | ± 361 | ± 0.26 | – |
| Inspection time | Sex | Group | BUN | GLU | TP | ALB | TCHO | TG | Na | K | Cl | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | ||||
| 5 days after administration | Male | Control | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
| Mean | 39.8 | 180 | 4.1 | 2.1 | 141 | 123 | 142 | 5.0 | 120 | |||
| ± S.D | ± 8.6 | ± 43 | ± 0.3 | ± 0.2 | ± 18 | ± 22 | ± 2 | ± 0.7 | ± 3 | |||
| 5 MBq/kg | N | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 8 | 9 | ||
| Mean | 39.0 | 150 | 4.3 | 2.2 | 123 | 90* | 144 | 4.8 | 122 | |||
| ± S.D | ± 7.7 | ± 44 | ± 0.2 | ± 0.1 | ± 14 | ± 23 | ± 3 | ± 0.6 | ± 4 | |||
| 20 MBq/kg | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 9 | 10 | ||
| Mean | 40.2 | 156 | 4.4 | 2.3 | 139 | 85** | 144 | 5.0 | 122 | |||
| ± S.D | ± 10.6 | ± 31 | ± 0.3 | ± 0.2 | ± 22 | ± 19 | ± 2 | ± 0.7 | ± 4 | |||
| 50 MBq/kg | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
| Mean | 36.5 | 162 | 4.4 | 2.2 | 132 | 96 | 145* | 4.9 | 121 | |||
| ± S.D | ± 7.8 | ± 44 | ± 0.5 | ± 0.1 | ± 21 | ± 40 | ± 4 | ± 1.0 | ± 4 |
| Inspection time | Sex | Group | AST | ALT | γ-GTP | LDH | ALP | CK | AMY | TBIL | CRE | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (IU/L) | (IU/L) | (IU/L) | (IU/L) | (IU/L) | (IU/L) | (IU/L) | (mg/dL) | (mg/dL) | ||||
| 5 days after administration | Female | Control | N | 10 | 4 | 0 | 10 | 10 | 10 | 10 | 10 | 0 |
| Mean | 41 | 16 | – | 795 | 377 | 315 | 2757 | 0.66 | - | |||
| ± S.D | ± 16 | ± 4 | – | ± 354 | ± 83 | ± 283 | ± 431 | ± 0.32 | - | |||
| 5 MBq/kg | N | 10 | 2 | 0 | 10 | 10 | 10 | 9 | 10 | 0 | ||
| Mean | 37 | 15 | – | 754 | 376 | 265 | 2770 | 0.66 | - | |||
| ± S.D | ± 11 | ± 3 | – | ± 391 | ± 75 | ± 220 | ± 165 | ± 0.23 | - | |||
| 20 MBq/kg | N | 9 | 4 | 0 | 9 | 10 | 10 | 10 | 9 | 1 | ||
| Mean | 35 | 14 | – | 704 | 374 | 594 | 2792 | 0.64 | 0.80 | |||
| ± S.D | ± 7 | ± 6 | – | ± 262 | ± 70 | ± 542 | ± 400 | ± 0.28 | - | |||
| 50 MBq/kg | N | 9 | 4 | 0 | 9 | 10 | 10 | 9 | 9 | 0 | ||
| Mean | 28 | 18 | – | 508 | 287* | 450 | 2474 | 0.57 | - | |||
| ± S.D | ± 10 | ± 8 | – | ± 169 | ± 61 | ± 447 | ± 356 | ± 0.26 | - |
| Inspection time | Sex | Group | BUN | GLU | TP | ALB | TCHO | TG | Na | K | Cl | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | ||||
| 5 days after administration | Female | Control | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
| Mean | 27.6 | 159 | 4.1 | 2.2 | 95 | 84 | 145 | 5.1 | 116 | |||
| ±S.D. | ±5.7 | ±38 | ±0.3 | ±0.1 | ±15 | ±29 | ±4 | ±0.7 | ±4 | |||
| 5 MBq/kg | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
| Mean | 32.2 | 156 | 4.0 | 2.2 | 107 | 77 | 146 | 5.0 | 116 | |||
| ±S.D. | ±5.9 | ±41 | ±0.4 | ±0.2 | ±18 | ±18 | ±6 | ±0.7 | ±3 | |||
| 20 MBq/kg | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 9 | 10 | ||
| Mean | 31.9 | 161 | 4.2 | 2.3 | 117* | 78 | 144 | 5.1 | 117 | |||
| ±S.D. | ±7.3 | ±25 | ±0.3 | ±0.2 | ±27 | ±23 | ±3 | ±0.8 | ±3 | |||
| 50 MBq/kg | N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 9 | 10 | ||
| Mean | 34.7 | 165 | 4.2 | 2.2 | 114 | 56* | 145 | 4.5 | 119 | |||
| ±S.D. | ±9.7 | ±37 | ±0.4 | ±0.2 | ±15 | ±24 | ±3 | ±0.5 | ±3 |
| Inspection time | Sex | Group | AST | ALT | γ-GTP | LDH | ALP | CK | AMY | TBIL | CRE | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (IU/L) | (IU/L) | (IU/L) | (IU/L) | (IU/L) | (IU/L) | (IU/L) | (mg/dL) | (mg/dL) | ||||
| 14 days after administration | Male | Control | N | 5 | 5 | 0 | 4 | 5 | 3 | 5 | 5 | 4 |
| Mean | 56 | 20 | – | 998 | 244 | 617 | 2655 | 0.80 | 0.30 | |||
| ±S.D. | ±8 | ±6 | – | ±262 | ±43 | ±436 | ±397 | ±0.41 | ±0.00 | |||
| 50 MBq/kg | N | 5 | 3 | 0 | 5 | 1 | 5 | 5 | 5 | 0 | ||
| Mean | 31** | 14 | – | 694 | 370 | 365 | 2612 | 0.32* | – | |||
| ±S.D. | ±8 | ±2 | – | ±363 | – | ±188 | ±334 | ±0.04 | – | |||
| Female | Control | N | 5 | 3 | 0 | 5 | 5 | 5 | 5 | 5 | 1 | |
| Mean | 46 | 14 | – | 976 | 281 | 544 | 2341 | 0.52 | 0.20 | |||
| ±S.D. | ±7 | ±2 | – | ±439 | ±76 | ±420 | ±73 | ±0.18 | – | |||
| 50 MBq/kg | N | 5 | 2 | 0 | 5 | 2 | 5 | 5 | 5 | 0 | ||
| Mean | 33* | 13 | – | 711 | 166 | 214 | 2071** | 0.48 | – | |||
| ±S.D. | ±4 | ±1 | – | ±273 | ±17 | ±141 | ±163 | ±0.11 | – |
| Inspection time | Sex | Group | BUN | GLU | TP | ALB | TCHO | TG | Na | K | Cl | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (mg/dL) | (mg/dL) | (g/dL) | (g/dL) | (mg/dL) | (mg/dL) | (mEq/L) | (mEq/L) | (mEq/L) | ||||
| 14 days after administration | Male | Control | N | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Mean | 52.0 | 177 | 4.1 | 1.9 | 130 | 74 | 140 | 4.6 | 123 | |||
| ±S.D. | ±20.0 | ±38 | ±0.3 | ±0.1 | ±28 | ±13 | ±3 | ±0.7 | ±1 | |||
| 50 MBq/kg | N | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | ||
| Mean | 33.8 | 198 | 4.6* | 2.2* | 196** | 75 | 140 | 4.2 | 123 | |||
| ±S.D. | ±6.5 | ±17 | ±0.3 | ±0.2 | ±14 | ±17 | ±3 | ±0.5 | ±6 | |||
| Female | Control | N | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |
| Mean | 29.0 | 164 | 4.1 | 2.1 | 111 | 73 | 144 | 4.6 | 120 | |||
| ±S.D. | ±4.4 | ±61 | ±0.1 | ±0.1 | ±14 | ±13 | ±2 | ±1.3 | ±1 | |||
| 50 MBq/kg | N | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | ||
| Mean | 22.6 | 204 | 4.8** | 2.4* | 171** | 64 | 145 | 3.9 | 119 | |||
| ±S.D. | ±5.4 | ±27 | ±0.3 | ±0.2 | ±17 | ±17 | ±2 | ±1.1 | ±2 |
AST Aspartate aminotransferase, ALT Alanine aminotransferase, γ-GTP γ-glutamyl transpeptidase, LDH Lactate dehydrogenase, ALP Alkaline phosphatase, CK Creatine kinase, AMY Amylase, TBIL Total bilirubin, CRE Creatinine, BUN Blood urea nitrogen, ALB Albumin, GLU Glucose, TP Total protein, TG Triglyceride, TCHO Total cholesterol, Na Sodium, K Potassium, Cl Chlorine
Significantly different from the control, **p < 0.01 (Dunnett-test)
Significantly different from the control, *p < 0.05, **p < 0.01 (Dunnett-test)