Table 3.

Necropsy findings—expanded single dose intravenous toxicity study of ²¹¹At-NaAt in mice -

Inspection time											5 days after administration
Sex											Male					Female
Group											Control	5 MBq/kg	20 MBq/kg	50 MBq/kg		Control	5 MBq/kg	20 MBq/kg	50 MBq/kg
No. of animals											10	10	10	10		10	10	10	10
No. of surviving animals											10	10	10	10		10	10	10	10
No. of dead animals											0	0	0	0		0	0	0	0
No. of no abnormality											10	8	10	8		10	9	10	10
Organ				Necropsy findings
Spleen				: Small in size							0	0	0	1		0	0	0	0
Testis				: Small in size (Left)							0	0	0	1		–	–	–	–
Epididymis				: Reddish color of the cauda epididymis (Right)							0	1	0	0		–	–	–	–
Abdominal cavity				: Black-red mass 3 mm in diameter							0	1	0	0		0	1	0	0
				in the mesentery of the liver

Inspection time	14 days after administration
Sex	Male		Female
Group	Control	50 MBq/kg	Control	50 MBq/kg
No. of animals	5	5	5	5
No. of surviving animals	5	5	5	5
No. of dead animals	0	0	0	0
No. of no abnormality	5	5	5	5