A, MR image (transverse T2-weighted fast-FLAIR images, 9900 ms/110 ms/2500 ms/1 [TR/TE/inversion time/acquisitions]) obtained in patient 1 at baseline, while showing signs of overt hepatic encephalopathy. The image shows multiple focal supratentorial WMLs (total lesion volume, 7,507 mm3). B, Patient 1 after improvement of hepatic encephalopathy: MR shows a clear reduction in size and number of these focal WMLs (final lesion volume of 2,033 mm3).