Table 1.

Clinical histological phenotype of patient myoblast samples.

LGMD2I	CMD
Well organised muscle tissue with normotrophic fibres and subsarcolemmal nuclei. Presence of some hypotrophic fibres. No degenerative aspects are observed. No pathological accumulation of PAS positive material. Predominance of type I fibre. Relative hypotrophy of type II fibres.	Severe alteration of the tissue organisation due to abundant peri and endomysial connective tissue, fibre anisometry with normo-, hyppo-, atrophic and various hypertrophic fibres some of which with splittings, central nuclei and rare degenerate fibres.
Conclusion: Modest, non-specific, myogenic changes.	Conclusion: Morphological features indicative of a severe dystrophic degeneration, compatible with the diagnosis of congenital muscular dystrophy