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. 2021 May 19;4:598. doi: 10.1038/s42003-021-02116-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Four CpGs were selected that revealed continuous changes during culture expansion in DNAm profiles of MSCs, fibroblasts, and HUVECs (all 450k BeadChip data, Supplemental Table S1). b DNAm at these four CpGs was then analyzed in a training set (n = 44, Supplemental Table S4) by pyrosequencing and the results were used to train a multivariable model to estimate passage numbers (RMSE root mean squared error, MAE mean average error). c This predictor was validated on pyrosequencing results of an independent set of samples (n = 83, Supplemental Data 2).