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. 2021 May 19;12(6):511. doi: 10.1038/s41419-021-03790-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Genes selectively dependent on MYCN for NB cell survival are enriched within a variety of GO terms of biological processes, and the top nine processes are shown according to p values. B GSEA assays of ferroptosis-related genes showing enrichment with MYCN amplification based on RNA-seq data of six human NB cell lines. ES, enrichment score. C GPX4 is shared between ferroptosis-related and MYCN-dependent survival genes. D Cell viabilities when different concentrations of the GPX4 inhibitor (1S, 3R)-RSL3 (RSL3) and system X_c(−) inhibitor Erastin were used as ferroptosis inducers in multiple human NB cell lines (MYCN amplified SK-N-BE2, BE(2)-C, NLF, SK-N-DZ, and Kelly are represented in pink; and MYCN non-amplified SHEP, SK-N-AS, and SY5Y are shown in black; n = 4). E Kaplan–Meier survival curves for NB patients based on GPX4 mRNA expression. Gene expression and clinical data were retrieved from GSE45547. F Correlation analysis between GPX4 and MYCN expression based on the data retrieved from GSE45547. *p < 0.05, **p < 0.01.