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. 2021 May 19;12(6):511. doi: 10.1038/s41419-021-03790-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Lipid peroxides were detected by flow cytometry after incubation with C11-BODIPY in SHEP (A) or SK-N-BE2 (B) cells with or without MYCN. DFO, desferrioxamine, n = 3. C Cell viabilities of SHEP cells with or without MYCN overexpression incubated with Erastin (left), RSL3 (middle), or RSL3 combined with either ferroptosis inhibitor (10 μM DFO, 1 μM Ferr-1), apoptosis inhibitor (20 μM z-VAD), or necroptosis inhibitor (2 μM Necrostatin-1) (right). D Cell viabilities of SK-N-BE2 cells with or without MYCN knockdown incubated with Erastin or RSL3. E Metabolic analysis of SHEP cells with or without MYCN. Z-score ±2.75 is corresponding to p = 0.01 and depicted as a dotted line. Data are presented as mean ± SD of three replicates. Two-tailed unpaired t-tests were performed to calculate p values. **p < 0.01.