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. 2021 May 19;12(6):511. doi: 10.1038/s41419-021-03790-w

Fig. 5. TFRC mediates MYCN–induced, GPX4-dependent ferroptosis.

Fig. 5

A Cell viability of SHEP cells with or without TFRC overexpression incubated with Erastin (left) or RSL3 (right). Cell viabilities of SHEP (B) or SK-N-BE2 (C) cells with or without TFRC depletion incubated with Erastin (left) or RSL3 (right). Amounts of cellular lipid peroxides measured by C11-BODIPY in SHEP (D) or SK-N-BE2 (E) cells with or without TFRC. Data are presented as mean ± SD of three replicates. Two-tailed unpaired t-tests were performed to calculate p values. **p < 0.01.