Fig. 2. Club cell-specific deletion of Pdcd5 prevents lung fibrosis.

a MTS was carried out on lung tissues from Pdcd5^f/f and Ccsp-Pdcd5^d/d mice with or without BLM treatment (scale bars = 200 μm). b–d MTS quantification and soluble collagen assay using lung tissues from Pdcd5^f/f and Ccsp-Pdcd5^d/d mice (b), Pdcd5^f/f and Spc-Pdcd5^d/d mice (c), and Ccsp-TGFβ₁-TG (d), respectively (n = 5 mice/group). Error bars represents mean ± s.e.m. Statistical analysis was performed with ANOVA with Tukey’s test. ***p < 0.001; *p = 0.029 (b–d). e Kaplan–Meier survival analysis was performed after BLM injection. Pdcd5^f/f (n = 7 mice) and Ccsp-Pdcd5^d/d (n = 8 mice), p = 0.0025. f Kaplan–Meier survival of Pdcd5^f/f and Spc-Pdcd5^d/d (n = 5 mice/group), p = 0.6731. Statistical analysis was performed using log-rank (Mantel–Cox) test (e, f). Source data are provided in the Source Data file.