Figure 4:

The effects of various levels of hypoxia on progenitor cell behavior. Severe continuous hypoxia seems to facilitate astrocytic transformation, whereas moderate hypoxia promotes precocious differentiation.Since self-renewal is important in the maintenance of the stem cell pool, both forms of hypoxia cause depletion of the progenitor pool leading to a net loss of available NSCs. The long term effect of progenitor pool depletion on lifelong learning and memory is not well understood. Xie Y, Lowery W. Methods 2018 with permission.