Antibodies
Reagent or Resource	Source	Identifier	Working concentration (primary antibodies)	Official website
GAPDH	ProteinTech	60004-1-Ig	1:10000	http://www.ptgcn.com/
mTOR	ProteinTech	20657-1-Ap	1:1000	http://www.ptgcn.com/
Phospho-mTOR (Ser2448)	Affinity	AF3308	1:1000	http://www.affbiotech.com/
LC3A/B	Abcam	ab128025	1:1000	https://www.abcam.com/
Goat-Anti-Rabbit IgG (H+L)HRP	Affinity	S0001	1:10000	http://www.affbiotech.com/
Goat-Anti-Mouse IgG (H+L)HRP	Affinity	S0002	1:10000	http://www.affbiotech.com/
GPX4	Affinity	DF6701	1:1000	http://www.affbiotech.com/
S100A4	Affinity	S100A4	1:1000	http://www.affbiotech.com/
p-Tau	Affinity	AF3308	1:1000	http://www.affbiotech.com/
Tau	Abcam	Ab32057	1:1000	https://www.abcam.com/
Amyloid β	Affinity	AF6084	1:1000	https://www.abcam.com/
APOE	Abcam	Ab204112	1:1000	https://www.abcam.com/
TREM2	Affinity	DF12529	1:1000	http://www.affbiotech.com/
CD33	Affinity	DF6789	1:1000	http://www.affbiotech.com/
TNF-α	Abcam	ab9579	1:1000	https://www.abcam.com/
NF-κB	Abcam	ab16502	1:1000	https://www.abcam.com/
Chemicals, Peptides, and Recombinant Proteins
Reagent or Resource			Source	Identifier
RNAiso Plus			Takara	9109
DNAiso Reagent			Takara	9770Q
Critical Commercial Assays
Reagent or Resource		Source	Identifier	Official website
Detection kit for β-galactosidase (β-Gal) activity		Solarbio	BC2580	http://www.solarbio.com/
TMR (Red) Tunel Cell Apoptosis Detection Kit		Servicebio	G1502	https://www.servicebio.cn/
TB Green Premix Ex Taq II (Tli RNaseH Plus)		Takara	RR820A	https://www.takarabiomed.com.cn/
Prussian blue staining kit		Servicebio	G1029	http://www.servicebio.cn/
Relative Mouse Telomere Length Quantification qPCR Assay Kit		ScienCell	#M8908	https://www.sciencellonline.com/
Deposited Data
RNA sequencing data		This paper		PRJNA669847