Table 2.
Genes with FDR < 0.05 and highlighted as interesting in previous literature.
| Previous studies | Our study | |||||||
|---|---|---|---|---|---|---|---|---|
| Gene | N | Test | Direction | Test | Average exp | Effect size (SE) | p value | Direction |
| YWHAZ [14] | 87 | R vs. NR (W4) | R↑ | TR (W8) | 3607.28 | 0.0014 (0.0015) | 0.3509 | TR↓ |
| NLGN2 [14] | 84 | R vs. NR (W12) | R↓ | TR (W8) | 0 | – | – | – |
| NLGN2 [14] | 61 | R vs. NR (BL) | R↓ | TR (BL) | 0 | – | – | – |
| NR2C2 [14] | 84 | R vs. NR (W12) | R↓ | TR (W8) | 536.27 | 0.0019 (0.0028) | 0.4814 | TR↓ |
| ZNF641 [14] | 84 | R vs. NR (W12) | R↓ | TR (W8) | 423.28 | 0.00077 (0.0026) | 0.7648 | TR↓ |
| FKBP1A [14] | 84 | R vs. NR (W12) | R↑ | TR (W8) | 433.95 | −0.0024 (0.0021) | 0.2541 | TR↑ |
| SMAD7 [10] | 77 | R vs. NR (BL) | R↓ | TR (BL) | 110.28 | 0.0012 (0.0028) | 0.6640 | TR↓ |
| SIGLECP3 [10] | 77 | R vs. NR (BL) | R↓ | TR (BL) | 23.93 | – | – | – |
| MMP28 [15] | 39 | TR (W8) | TR↑ | TR (W8) | 0.60 | – | – | – |
| KXD1 [15] | 39 | TR (W8) | TR↓ | TR (W8) | 89.01 | 0.0030 (0.0029) | 0.3003 | TR↓ |
| IRF7 [11] | 63 | TR (BL) | TR↑ | TR (BL) | 0.69 | – | – | – |
R = responders or remitters definitions are different between studies; TR↑ = increased expression result in greater response; R↑ = responders have higher expression compared to NR; – = have less than six counts for more than 200 patients.
NR non-responders, TR treatment response (continious varibale).