Table 3.
Parameters describing variance across all genes for each covariate in the experimental design.
| Covariates | Median variance (%) |
Mean variance (%) |
No. of genes >5% | No. of genes >2% | No. of genes >1% | Max variance (%) |
|---|---|---|---|---|---|---|
| Sex | 2.51 × 10−7 | 0.34 | 184 | 419 | 875 | 48.63 |
| Age | 0.07 | 0.22 | 23 | 159 | 573 | 12.70 |
| Visit | 5.33 × 10−8 | 0.03 | 0 | 0 | 14 | 1.22 |
| Treatment type | 3.92 × 10−8 | 0.03 | 0 | 5 | 44 | 3.74 |
| Symptom severity at baseline | 0.05 | 0.12 | 0 | 7 | 92 | 2.71 |
| Treatment response | 0.06 | 0.18 | 1 | 38 | 388 | 5.52 |
| PEER factor 1 | 2.40 | 4.32 | 3808 | 7274 | 9134 | 73.02 |
| PEER factor 2 | 8.00 | 13.33 | 8094 | 10096 | 11099 | 82.02 |
| PEER factor 3 | 11.37 | 16.93 | 8896 | 10632 | 11405 | 91.74 |
| PEER factor 4 | 0.87 | 1.73 | 1147 | 3871 | 6142 | 31.07 |
| PEER factor 5 | 4.52 | 6.83 | 6333 | 8991 | 10239 | 59.64 |
| PEER factor 6 | 0.87 | 1.66 | 731 | 3845 | 6247 | 38.76 |
| PEER factor 7 | 4.28 | 8.24 | 6249 | 8481 | 9771 | 81.23 |
| Subject | 5.13 | 7.69 | 6864 | 10432 | 11452 | 90.55 |
| Residuals | 34.32 | 38.34 | 13379 | 13416 | 13416 | 97.56 |
Median variance = median variance across all genes; Mean variance = mean variance across all genes; No. of genes > X% = No. of genes for which the covariate explains more than X% of the variance. Max variance = variance of the gene for which the covariate explains the most variance.