Table 2.
Analyses of measures of depressive symptoms.
| PReDicT group | TaU group | ||||||
|---|---|---|---|---|---|---|---|
| Categorical outcomes | |||||||
| Time point | N | % (95% CI) | N | % (95% CI) | Odds ratio (95% CI) | P value | |
| QIDS-SR-16 response (primary outcome) | Week 8 | 392 | 55.91 (48.52, 63.05) | 389 | 51.8 (44.44, 59.08) | 1.18 (0.89, 1.56) | 0.250 |
| QIDS-SR-16 remission | Week 8 | 392 | 35.17 (27.69, 43.45) | 389 | 36.16 (28.49, 44.61) | 0.96 (0.69, 1.32) | 0.792 |
| MADRS response | Week 8 | 378 | 57.61 (51.47, 63.53) | 372 | 58.44 (52.32, 64.31) | 0.97 (0.73, 1.28) | 0.812 |
| MADRS remission | Week 8 | 378 | 29.03 (23.88, 34.78) | 372 | 28.56 (23.48, 34.23) | 1.02 (0.76, 1.38) | 0.880 |
| Continuous outcomes | |||||||
|---|---|---|---|---|---|---|---|
| Time point | N | Mean change (95% CI) | N | Mean change (95% CI) | Difference between groups (95% CI) | P value | |
| QIDS-SR-16 sadness item | Week 8 | 392 | −1.34 (−1.46, −1.23) | 389 | −1.28 (−1.40, −1.16) | 0.06 (−0.06, 0.18) | 0.295 |
| QIDS-SR-16 restlessness item | Week 8 | 392 | −0.53 (−0.62, −0.43) | 389 | −0.44 (−0.54, −0.34) | 0.09 (−0.03, 0.20) | 0.133 |
| MADRS | Week 8 | 378 | −14.55 (−15.57, −13.54) | 372 | −14.46 (−15.49, −13.43) | 0.10 (−1.03, 1.23) | 0.867 |
| QIDS-SR-16 | |||||||
| Week 8 | 392 | −7.70 (−8.51, −6.89) | 389 | −7.30 (−8.12, −6.89) | 0.4 (−0.28, 1.07) | 0.250 | |
| Week 24 | 276 | −8.10 (−8.94, −7.26) | 262 | −7.76 (−8.59, −7.26) | 0.29 (−0.4, 0.99) | 0.361 | |
| Week 48 | 229 | −8.95 (−9.77, −8.13) | 233 | −8.71 (−9.59, −7.83) | 0.24 (−0.54, 1.02) | 0.547 | |
Primary outcome highlighted in bold. QIDS-SR-16 quick inventory of depressive symptoms, 16-item self-report version, MADRS Montgomery–Åsberg Depression Rating Scale. Cut off scores for remission= QIDS-SR-16 ≤ 5, MADRS ≤ 7.