Table 2.
Hazard ratio based on method of propensity score analysis
| Method | TD-TKI (primary endpoint) |
Overall survival (secondary endpoint) |
||||
|---|---|---|---|---|---|---|
| N | HR (95% CI) | P value | N | HR (95% CI) | P value | |
| IPTW | 540 | 1.146 (0.929-1.414) | 0.204 | 540 | 1.470 (1.070-2.021) | 0.018 |
| Sensitivity analysis | ||||||
| Unadjusted | 550 | 1.090 (0.814-1.459) | 0.565 | 550 | 1.217 (0.783-1.893) | 0.383 |
| Matching (1 to 1) | 376 | 1.010 (0.701-1.455) | 0.959 | 376 | 1.141 (0.639-2.037) | 0.657 |
| Stabilized IPTW | 540 | 1.134 (0.842-1.528) | 0.408 | 540 | 1.450 (0.924-2.275) | 0.106 |
| Truncated IPTW | 529 | 1.169 (0.943-1.450) | 0.155 | 529 | 1.385 (0.998-1.922) | 0.052 |
| Method | TTF (secondary endpoint) |
PFS (secondary endpoint) |
||||
|---|---|---|---|---|---|---|
| N | HR (95% CI) | P value | N | HR (95% CI) | P value | |
| IPTW | 540 | 0.924 (0.755-1.131) | 0.443 | 540 | 1.020 (0.812-1.281) | 0.864 |
| Sensitivity analysis | ||||||
| Unadjusted | 550 | 0.882 (0.667-1.167) | 0.379 | 550 | 0.980 (0.716-1.340) | 0.898 |
| Matching (1 to 1) | 376 | 0.817 (0.575-1.163) | 0.262 | 376 | 1.003 (0.686-1.468) | 0.987 |
| Stabilized IPTW | 540 | 0.914 (0.687-1.214) | 0.534 | 540 | 1.000 (0.726-1.377) | >0.99 |
| Truncated IPTW | 529 | 0.932 (0.758-1.145) | 0.501 | 529 | 1.038 (0.825-1.305) | 0.751 |
CI, confidence interval; HR, hazard ratio; IPTW, inverse probability of treatment weighting; PFS., progression-free survival.