Figure 5.

Single subject images from a patient with posterior cortical atrophy (top row), a patient with amnestic Alzheimer's disease (center row), and a healthy control subject (bottom row). The posterior cortical atrophy subject showed focal occipito-temporal [¹¹C]PBR28 binding, with FDG hypometabolism in the same region (arrows). While the posterior cortical atrophy subjects showed occipito-temporal PIB binding, PIB binding was also found in frontal cortex. The subject with amnestic Alzheimer's disease showed more diffuse [¹¹C]PBR28 binding, with occipital sparing on PIB and classic bilateral temporo-parietal hypometabolism on FDG imaging. The control subject showed low amounts of diffuse [¹¹C]PBR28 binding and absence of cortical PIB [¹¹C]PIB binding. Courtesy from Kreisl et al. (2016b).