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. 2021 May 6;13:624330. doi: 10.3389/fnagi.2021.624330

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Copyright © 2021 Bao, Xie, Zuo, Guan and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Averaged [¹⁸F]FEOBV VAChT PET (A,B), [¹⁸F]FDG PET (C,D), and [¹⁸F]NAV4694 Aβ PET (E,F) images of healthy controls (A,C,E) and AD patients (B,D,F). PET images in control subjects revealed the greatest [¹⁸F]FEOBV uptake in brain areas known to be the most innervated by the cholinergic systems, including the striatum, thalamus, cerebral cortex as a whole, hippocampal area and cerebellum (A). In AD patients, PET imaging revealed a significant reduction of [¹⁸F]FEOBV uptake in comparison with control subjects (B). Distinct cerebral hypometabolism (D) and amyloid deposition (F) were seen in the AD patients, as compared to control subjects (C,E). Courtesy from Aghourian et al. (2017).