Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 6;12:663495. doi: 10.3389/fimmu.2021.663495

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Liu, Yang and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Landscape of immune cells infiltration in melanoma. (A) Unsupervised clustering heatmap of immune cells infiltration for all melanoma samples. Rows represent tumor-infiltrating immune cells, and columns represent samples. (B) The correlation coefficient heatmap of immune cell interaction. (C) Kaplan-Meier curves of overall survival for ICI cluster A–C. Log rank test P = 0.007. (D) The box plot of immune cells fraction in ICI cluster A–C. *P<0.05; **P < 0.01; ***P<0.001; ****P<0.0001; ns: no significance. (E) The box plot of immune activity related signature genes expression (CXCL9, CXCL10, TNF, IFNG, CD8A, GZMA, GZMB, PRF1) between ICI cluster A–C, ****P<0.0001. (F) The box plot of immune checkpoint signature genes expression (CTLA4, PDCD1, PDCD1LG2, LAG3) between ICI cluster A-C, ****P<0.0001.