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. 2021 May 6;12:663495. doi: 10.3389/fimmu.2021.663495

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Copyright © 2021 Liu, Yang and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of ICI score. (A) Alluvial diagram of ICI scores groups distribution in different gene cluster, and survival outcomes. (B) Kaplan-Meier curves of overall survival for high and low ICI score cluster in all sample. Log rank test P <0.001. (C) Kaplan-Meier curves of overall survival for high and low ICI score cluster in TCGA cohort. Log rank test P <0.001. (D) GSEA of high and low ICI score groups for all melanoma samples. (E) The box plot of immune activity related signature genes expression (CXCL9, CXCL10, TNF, IFNG, CD8A, GZMA, GZMB, PRF1) in high and low ICI score, ****P<0.0001. (F) The box plot of immune checkpoint signature genes expression (CTLA4, PDCD1, PDCD1LG2, LAG3) in high and low ICI score, ****P<0.0001.