Table 1.
The Correlation between the ICI Scores and Somatic Variants.
| Gene | H-wild | H-mutation | L-wild | L-mutation | P value |
|---|---|---|---|---|---|
| GLRB | 192(97.46%) | 5(2.54%) | 221(88.4%) | 29(11.6%) | 0.000653446 |
| ACSM1 | 192(97.46%) | 5(2.54%) | 226(90.4%) | 24(9.6%) | 0.004861082 |
| ITGAX | 194(98.48%) | 3(1.52%) | 231(92.4%) | 19(7.6%) | 0.006359613 |
| SEL1L3 | 193(97.97%) | 4(2.03%) | 229(91.6%) | 21(8.4%) | 0.006885403 |
| LRRC4C | 185(93.91%) | 12(6.09%) | 214(85.6%) | 36(14.4%) | 0.007742623 |
| CATSPERD | 178(90.36%) | 19(9.64%) | 242(96.8%) | 8(3.2%) | 0.008300153 |
| MYH4 | 172(87.31%) | 25(12.69%) | 193(77.2%) | 57(22.8%) | 0.008825349 |
| PKHD1 | 183(92.89%) | 14(7.11%) | 211(84.4%) | 39(15.6%) | 0.009043977 |
| ATP13A4 | 188(95.43%) | 9(4.57%) | 220(88%) | 30(12%) | 0.009448039 |
| IGSF10 | 184(93.4%) | 13(6.6%) | 213(85.2%) | 37(14.8%) | 0.009879668 |
| EXPH5 | 189(95.94%) | 8(4.06%) | 222(88.8%) | 28(11.2%) | 0.0099167 |
| RXFP2 | 193(97.97%) | 4(2.03%) | 230(92%) | 20(8%) | 0.010213103 |
| PDGFRA | 192(97.46%) | 5(2.54%) | 228(91.2%) | 22(8.8%) | 0.010494566 |
| MPP7 | 187(94.92%) | 10(5.08%) | 219(87.6%) | 31(12.4%) | 0.012475552 |
| FHDC1 | 193(97.97%) | 4(2.03%) | 231(92.4%) | 19(7.6%) | 0.015072759 |
| BTBD11 | 191(96.95%) | 6(3.05%) | 227(90.8%) | 23(9.2%) | 0.015127514 |
| ADGRF4 | 192(97.46%) | 5(2.54%) | 229(91.6%) | 21(8.4%) | 0.015293351 |
| CSF2RB | 192(97.46%) | 5(2.54%) | 229(91.6%) | 21(8.4%) | 0.015293351 |
| TGM6 | 182(92.39%) | 15(7.61%) | 244(97.6%) | 6(2.4%) | 0.018201576 |
| LRP1B | 143(72.59%) | 54(27.41%) | 154(61.6%) | 96(38.4%) | 0.019185781 |
| SZT2 | 190(96.45%) | 7(3.55%) | 226(90.4%) | 24(9.6%) | 0.020842861 |
| DNAH1 | 173(87.82%) | 24(12.18%) | 236(94.4%) | 14(5.6%) | 0.021072363 |
| IGHM | 192(97.46%) | 5(2.54%) | 230(92%) | 20(8%) | 0.022153014 |
| PPP1R3A | 176(89.34%) | 21(10.66%) | 203(81.2%) | 47(18.8%) | 0.02467418 |
| TRPC4 | 184(93.4%) | 13(6.6%) | 216(86.4%) | 34(13.6%) | 0.02506211 |
| ZNF99 | 184(93.4%) | 13(6.6%) | 216(86.4%) | 34(13.6%) | 0.02506211 |
| NBEA | 182(92.39%) | 15(7.61%) | 213(85.2%) | 37(14.8%) | 0.027528675 |
| PDZD2 | 185(93.91%) | 12(6.09%) | 218(87.2%) | 32(12.8%) | 0.027530981 |
| PCDHB7 | 189(95.94%) | 8(4.06%) | 225(90%) | 25(10%) | 0.027672056 |
| FAT4 | 156(79.19%) | 41(20.81%) | 174(69.6%) | 76(30.4%) | 0.029178661 |
| PLEKHH2 | 192(97.46%) | 5(2.54%) | 231(92.4%) | 19(7.6%) | 0.031882714 |
| GRM4 | 193(97.97%) | 4(2.03%) | 233(93.2%) | 17(6.8%) | 0.032281736 |
| CACNA2D4 | 193(97.97%) | 4(2.03%) | 233(93.2%) | 17(6.8%) | 0.032281736 |
| PTPRB | 174(88.32%) | 23(11.68%) | 201(80.4%) | 49(19.6%) | 0.032897855 |
| FCGBP | 182(92.39%) | 15(7.61%) | 214(85.6%) | 36(14.4%) | 0.03656706 |
| SI | 175(88.83%) | 22(11.17%) | 203(81.2%) | 47(18.8%) | 0.037014862 |
| FLG | 158(80.2%) | 39(19.8%) | 178(71.2%) | 72(28.8%) | 0.037794192 |
| PCDHA12 | 189(95.94%) | 8(4.06%) | 226(90.4%) | 24(9.6%) | 0.038406702 |
| HTT | 189(95.94%) | 8(4.06%) | 226(90.4%) | 24(9.6%) | 0.038406702 |
| SERPINB7 | 180(91.37%) | 17(8.63%) | 241(96.4%) | 9(3.6%) | 0.040168226 |
| ACE | 190(96.45%) | 7(3.55%) | 228(91.2%) | 22(8.8%) | 0.041099422 |
| TRPM6 | 181(91.88%) | 16(8.12%) | 213(85.2%) | 37(14.8%) | 0.043279955 |
| EML5 | 191(96.95%) | 6(3.05%) | 230(92%) | 20(8%) | 0.043557638 |
| PRLR | 187(94.92%) | 10(5.08%) | 223(89.2%) | 27(10.8%) | 0.044684979 |
| SLITRK3 | 187(94.92%) | 10(5.08%) | 223(89.2%) | 27(10.8%) | 0.044684979 |
| FSIP2 | 184(93.4%) | 13(6.6%) | 218(87.2%) | 32(12.8%) | 0.044972848 |
| PLCE1 | 179(90.86%) | 18(9.14%) | 210(84%) | 40(16%) | 0.045282963 |
| ANK3 | 153(77.66%) | 44(22.34%) | 172(68.8%) | 78(31.2%) | 0.047485414 |
| DNAH10 | 169(85.79%) | 28(14.21%) | 195(78%) | 55(22%) | 0.047763319 |
| DUOX2 | 188(95.43%) | 9(4.57%) | 225(90%) | 25(10%) | 0.048733515 |