Figure 8.
Inflammation is further alleviated in the brains of Pbyop1Δ parasite-infected mice. (A) IFN-γ, TNF-α, granzyme B, and perforin mRNA expression relative to β-actin in brains from mice infected with 104 or 106 Pbyop1Δ parasites was evaluated by real-time PCR 7 and 11 dpi. (B) Representative image and quantification of caspase-3 expression in the brain 7 and 11 dpi. Data are presented as mean ± SD (n = 5/group) and are representative of three independent experiments. *P < 0.05, **P < 0.01; ns, not significant as determined by the Mann-Whitney U test.