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(A) Hematoxylin and eosin (H&E) of a polypoid neoplasm taken from a POEMS patient with hemangiomas at the baseline. Scale bars, 500 μm. (B) VEGF immunostaining of the same hemangioma in (A) Scale bars, 500 μm. (C) VEGF immunostaining of a hemangioma taken at the end of therapy. (D) Magnification of a section shown in (C). VEGF staining is strongly positive in hyperplastic endothelial cells with epidermal atrophy and dilated capillary networks. Scale bars, 100 μm.
